Effect of long-term inhalation of low-dose budesonide on bone mineral density in children with asthma
长期吸入小剂量布地奈得对哮喘儿童骨密度的影响

摘要

目的 长期吸入小剂量布地奈得对哮喘儿童骨密度的影响。方法 采用回顾性方法，选取2019年10月-2020年10月以来我院收治的20例哮喘儿童的临床资料为研究组，选定通气20例健康儿童为常模组。给予研究组所有患儿长期小剂量布地奈得鼻喷雾剂吸入治疗，查证临床记录结果比较两组研究对象骨密度达标率。结果 常模组骨密度T值达标率90.00%（18/20）与研究组骨密度T值达标率90.00%（18/20），两组数据差异没有统计学意义（P>0.05）；常模组骨密度Z值达标率90.00%（18/20）与研究组骨密度Z值达标率90.00%（18/20），两组数据差异没有统计学意义（P>0.05）。结论 长期吸入小剂量布地奈得对哮喘儿童骨密度的影响效果不确切，同正常患儿一样，不影响其骨密度发育，具有较为明确的临床应用推广价值。

Abstract

Objective: The effect of long-term inhalation of low-dose budesonide on bone mineral density in children with asthma.
Methods: Using a retrospective method, the clinical data of 20 children with asthma admitted to our hospital from October 2019 to October 2020 were selected as the research group, and 20 healthy children with ventilation were selected as the regular module. All children in the study group were given long-term low-dose budesonide nasal spray inhalation treatment, and the clinical record results were verified to compare the bone mineral density attainment rate of the two groups of study subjects.
Results: The standard BMD T value compliance rate was 90.00% (18/20) and the study group BMD T value compliance rate was 90.00% (18/20). There was no statistically significant difference between the two groups (P>0.05); There was no statistically significant difference in the Z value of the modular bone mineral density (18/20) and 90.00% (18/20) of the study group.
Conclusion  : The effect of long-term inhalation of low-dose budesonide on the bone mineral density of children with asthma is not exact. Like normal children, it does not affect the development of bone mineral density. It has clear clinical application and promotion value.