Clinical analysis of gastrointestinal and duodenal ulcers in gastroenterology
消化内科胃及十二指肠溃疡药物治疗临床分析

摘要

目的 探析药物治疗消化内科胃及十二指肠溃疡的临床效果。方法 本研究开展时间为2019年1月-2020年1月，便利选取该时间段内我院消化内科收治的十二指肠溃疡患者72例作为主要研究对象。采随机双盲选法将患者分到对照组和观察组，两组分别36例患者，采用不同的药物治疗方法，分别是奥美拉唑治疗、泮托拉唑钠肠溶片治疗。患者接受不同药物治疗后对其临床状况进行观察和分析，并统计相关数据，尤其是患者治疗后的总有效率、（Helicobacter pylori，H.pylori）抗幽门螺杆菌复发率和根除率以及并发症发生率等数据要纤细记录，同时两组数据进行比较。结果 通过对患者的临床状况观察发现，采用泮托拉唑钠肠溶片治疗的观察组和使用奥美拉唑治疗的对照组，比较治疗总有效率，观察组相对较高，差异有统计学意义（P＜0.05）。此外，两组H.pylori根除率和复发率相比，观察组相对低于对照组，差异有统计学意义（P＜0.05）；两组患者并发症发生率比较，对照组相对较高，差异有统计学意义（P＜0.05）。结论 通过研究表明，在消化内科胃及十二指肠溃疡的治疗中，采用泮托拉唑钠肠溶片治疗具有较高的效果，不仅能够减少并发症的发生率，还能够提高H.pylori根除率减少其复发率。

Abstract

Objective: To explore the clinical effects of drugs on gastric and duodenal ulcers in gastroenterology.
Methods: This study was conducted from January 2019 to January 2020. It is convenient to select 72 patients with duodenal ulcers admitted to our hospital's gastroenterology department as the main research object. The patients were divided into a control group and an observation group by random double-blind selection. 36 patients in each group were treated with different drugs, including omeprazole and pantoprazole sodium enteric-coated tablets. Observation and analysis of the clinical status of patients after receiving different drugs, and statistics of relevant data, especially the total effective rate of patients after treatment, (Helicobacter pylori, H. pylori) anti-Helicobacter pylori recurrence rate and eradication rate and complications data such as incidence rate should be recorded slenderly, and two sets of data should be compared at the same time.
Results: Through observation of the clinical status of the patients, it was found that the observation group treated with pantoprazole sodium enteric-coated tablets and the control group treated with omeprazole compared the total treatment efficiency, the observation group was relatively high, and the difference was statistical significance (P ＜ 0.05). In addition, compared with the H.pylori eradication rate and recurrence rate of the two groups, the observation group was relatively lower than the control group, the difference was statistically significant (P <0.05); the incidence of complications between the two groups was relatively higher, and the control group was relatively higher. It is statistically significant (P <0.05).
Conclusion  : Studies have shown that in the treatment of gastric and duodenal ulcers in gastroenterology, pantoprazole sodium enteric-coated tablets have a higher effect, which can not only reduce the incidence of complications, but also increase eradication rate of the H. pylori,as well as reduce its recurrence rate.