Evaluation of Inflammatory Cytokines and Humoral Immunodynamic Detection on Mycoplasma Pneumonia in Children
炎性细胞因子与体液免疫动态检测对小儿支原体肺炎的评估作用及护理

摘要

目的 分析炎性细胞因子与体液免疫动态监测对小儿支原体肺炎的评估作用。方法 本次实验中需选取60例儿童作为研究对象，其中30例为存在支原体肺炎的患儿，其余30例为健康儿童，分别作为患儿组与健康组。在对照实验开始后，采集两组患儿血液样本进行炎性细胞因子与体液免疫动态检测，并对比检测结果。结果 患儿组重型、轻型支原体肺炎患儿的C3、C4、IgM、IgC、IgA等免疫球蛋白、补体水平指标与健康组小儿差异较大，存在统计学意义，（P＜0.05）。其次，患儿组重型支原体肺炎患儿TNF-α（98.31±9.26）pg/ml，IL-13（246.02±45.87）pg/ml，IL-10（11.07±4.23）pg/ml，IL-8（125.72±49.69）pg/ml；轻型患儿分别为（63.08±8.02）pg/ml、（155.41±24.09）pg/ml、（17.84±5.13）pg/ml、（72.92±40.16）pg/ml。健康组患儿上述炎性细胞因子水平分别为（40.61±2.29）pg/ml、（80.47±10.31）pg/ml、（24.10±5.93）pg/ml、（28.97±6.51）pg/ml。两组数据间存在统计学意义，（P＜0.05）。结论 支原体肺炎炎症反应极强，会对患儿身体造成较为严重的伤害，通过实施炎性细胞因子检测及体液免疫动态检测能够更加综合且精准的评估患儿具体病症情况，对后续针对性治疗有积极帮助。

Abstract

Objective: To analyze the effect of dynamic monitoring of inflammatory cytokines and humoral immunity on mycoplasmal pneumonia in children.
Methods: In this experiment, 60 children were selected as the research object, 30 of which were children with mycoplasma pneumonia, and the remaining 30 were healthy children, which were used as the children group and the healthy group, respectively. After the start of the control experiment, blood samples of two groups of children were collected for dynamic detection of inflammatory cytokines and humoral immunity, and the results were compared.
Results: The C3, C4, IgM, IgC, IgA and other immunoglobulin and complement levels of children with severe and mild mycoplasma pneumonia in the children group were significantly different from those in the healthy group (P <0.05). Secondly, children with severe mycoplasma pneumonia had TNF-α (98.31 ± 9.26) pg / ml, IL-13 (246.02 ± 45.87) pg / ml, IL-10 (11.07 ± 4.23) pg / ml, IL-8 ( 125.72 ± 49.69) pg / ml; light-weight children were (63.08 ± 8.02) pg / ml, (155.41 ± 24.09) pg / ml, (17.84 ± 5.13) pg / ml, (72.92 ± 40.16) pg / ml. The levels of inflammatory cytokines in healthy children were (40.61 ± 2.29) pg / ml, (80.47 ± 10.31) pg / ml, (24.10 ± 5.93) pg / ml, (28.97 ± 6.51) pg / ml. There was statistical significance between the two groups of data (P <0.05).
Conclusion  : Mycoplasma pneumonia has an extremely strong inflammatory response, which will cause more serious damage to the child's body. Through the implementation of inflammatory cytokine detection and humoral immune dynamic detection, it is possible to more comprehensively and accurately assess the specific conditions of children, and it will actively help subsequent targeted treatment.